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4 July 2023 | ARTICLE
Trends in oral anticoagulant prescription in patients with nonvalvular atrial fibrillation in Flanders and the impact of switching patients from vitamin K antagonists to DOACS in terms of the burden caused by complications of the disease: a registry-based study
CONTEXT: Since the introduction of direct oral anticoagulants (DOACs) for the treatment of nonvalvular atrial fibrillation (Afib), oral anticoagulants (OACs) prescription has evolved. AIM: We aim first to explore the OACs prescription behaviour in...
Auteurs: Elvire Nakhoul, Bert Vaes, Pavlos Mamouris et Jean-Marie Degryse
1 November 2022 | ARTICLE
Trends in prevalence and incidence of registered dementia and trends in multimorbidity among patients with dementia in general practice in Flanders, Belgium, 2000-2021: a registry-based, retrospective, longitudinal cohort study
OBJECTIVES: With the ageing of our population, it seems plausible that the prevalence of both dementia and multimorbidity will increase in the following decades. The aim of this study is to examine the trends in prevalence and incidence of registe...
Auteurs: Simon Gabriel Beerten, Antje Helsen, Jan De Lepeleire, Frans Boch Waldorff et Bert Vaes
23 September 2022 | ARTICLE
Evolution of benzodiazepine receptor agonist prescriptions in general practice: A registry-based study
BACKGROUND: Contrary to most European guidelines, benzodiazepine receptor agonists (BZRA) are often used continuously at a low dosage, being the most common form of long-term use. In Belgium, BZRA use is monitored by analyzing self-report data abo...
Auteurs: Kristien Coteur, Pavlos Mamouris, Bert Vaes, Marc Van Nuland, Catharina Mathei et Birgitte Schoenmakers
Auteurs: Simon Beerten, Jan Vandamme, jonas Crèvecoeur, steve Van den Bulck, bert Aertgeerts, nicolas Delvaux, gijs Van Pottelbergh, mieke Vermandere, laura Tops, thomas Neyens et bert Vaes
20 July 2022 | ARTICLE
Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020)
BACKGROUND: To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. METHODS: A retrospective study using data from 45 to 104 general practices (2000 to 202...
Auteurs: Hanne A Boon, Thomas Struyf, Jonas Crevecoeur, Nicolas Delvaux, Gijs Van Pottelbergh, Bert Vaes, Ann Van den Bruel et Jan Y Verbakel
28 June 2022 | ARTICLE
Trends in the epidemiology of depression and comorbidities from 2000 to 2019 in Belgium
BACKGROUND: Depression is a common mental disorder in family practice with an impact on global health. The aim of this study is to provide insight in the trends of epidemiological measures as well as pharmacological treatments and comorbidities of...
Auteurs: Roosje Walrave, Simon Gabriel Beerten, Pavlos Mamouris, Kristien Coteur, Marc Van Nuland, Gijs Van Pottelbergh, Lidia Casas et Bert Vaes
30 April 2022 | TESTING
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Auteurs: Laure Sillis, Veerle Foulon, Karel Allegaert, Annick Bogaerts, Maarten De Vos, Titia Hompes, Anne Smits, Kristel Van Calsteren, Jan Verbakel et Michael Ceulemans
1 January 2022 | ARTICLE
The impact of the Covid-19 pandemic on the incidence of diseases and the provision of primary care: A registry-based study.
INTRODUCTION: The Covid-19 pandemic had a tremendous impact on healthcare but uncertainty remains about the extent to which primary care provision was affected. Therefore, this paper aims to assess the impact on primary care provision and the evol...
Auteurs: Steve Van den Bulck, Jonas Crèvecoeur, Bert Aertgeerts, Nicolas Delvaux, Thomas Neyens, Gijs Van Pottelbergh, Patrick Coursier et Bert Vaes
30 December 2021 | ARTICLE
Pneumococcal vaccination prevented severe LRTIs in adults: a causal inference framework applied in registry data
OBJECTIVES: We estimated the effect of pneumococcal vaccination (PV) on acute lower respiratory tract infections (LRTIs) in various age and risk groups using different methods within a causal inference methodological framework. STUDY DESIGN AND SE...
Auteurs: Pavlos Mamouris, Severine Henrard, Geert Molenberghs, Jan Verhaegen, Guohao Lin et Bert Vaes
1 December 2021 | ARTICLE
Use of antibiotics and colorectal cancer risk: a primary care nested case-control study in Belgium
OBJECTIVES: To examine the association between the use of oral antibiotics and subsequent colorectal cancer risk. DESIGN: Matched case-control study. SETTING: General practice centres participating in the Integrated Computerised Network database i...
Auteurs: Johannes Van der Meer, Pavlos Mamouris, Vahid Nassiri, Bert Vaes et Marjan van den Akker
17 September 2021 | ARTICLE
An automated data cleaning method for Electronic Health Records by incorporating clinical knowledge
BACKGROUND: The use of Electronic Health Records (EHR) data in clinical research is incredibly increasing, but the abundancy of data resources raises the challenge of data cleaning. It can save time if the data cleaning can be done automatically. ...
Auteurs: Xi Shi, Charlotte Prins, Gijs Van Pottelbergh, Pavlos Mamouris, Bert Vaes et Bart De Moor
21 June 2021 | ARTICLE
Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study
AIMS: This study aims to assess the prevalence of atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), chronic kidney disease (CKD), and their combined presence in type 2 diabetes (T2D) patients in primary care for whom the 2019 ADA...
Auteurs: Geert Goderis, Bert Vaes, Pavlos Mamouris, Eline van Craeyveld et Chantal Mathieu
4 May 2021 | ARTICLE
The effect of automated audit and feedback on data completeness in the electronic health record of the general physician: protocol for a cluster randomized controlled trial
BACKGROUND: The electronic health record (EHR) of the general physician (GP) is an important tool that can be used to assess and improve the quality of healthcare. However, there are some problems when (re) using the data gathered in the EHR for q...
Auteurs: Steve van den Bulck, Tine De Burghgraeve, Willem Raat, Pavlos Mamouris, Patrick Coursier, Patrik Vankrunkelsven, Geert Goderis, Rosella Hermens, Gijs Van Pottelbergh et Bert Vaes
2 April 2021 | ARTICLE
Fast and optimal algorithm for case-control matching using registry data: application on the antibiotics use of colorectal cancer patients
BACKGROUND: In case-control studies most algorithms allow the controls to be sampled several times, which is not always optimal. If many controls are available and adjustment for several covariates is necessary, matching without replacement might ...
Auteurs: Pavlos Mamouris, Vahid Nassiri, Geert Molenberghs, Marjan van den Akker, Joep van der Meer et Bert Vaes
1 April 2021 | ARTICLE
Burden of infections on older patients presenting to general practice: a registry-based study
BACKGROUND: Estimates on the incidence rates of infections are needed to assess the burden of disease in the community. OBJECTIVE: To assess incidence rates of potentially serious infections in patients aged 65 years and over presenting to Flemish...
Auteurs: Thomas Struyf, Shauni Nuyts, Jos Tournoy, Bert Vaes, Jan Y Verbakel et Ann Van den Bruel
3 January 2021 | ARTICLE
Polypharmacy and excessive polypharmacy in community-dwelling middle aged and aged adults between 2011 and 2015
AIMS: We aimed to assess the prevalence, components and evolution of polypharmacy and to evaluate risk factors associated with polypharmacy. METHODS: A retrospective dynamic cohort study was performed, using a primary healthcare database comprisin...
Auteurs: Laura Hellemans, Shauni Nuyts, Julie Hias, Marjan van den Akker, Gijs Van Pottelbergh, Xavier Rygaert, Isabel Spriet, Bert Vaes, Jos Tournoy et Lorenz van der Linden
1 January 2021 | ARTICLE
Comorbidity burden in the first three years after diagnosis in patients with rheumatoid arthritis, psoriatic arthritis or spondyloarthritis: a general practice registry-based study
OBJECTIVES: Rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA) are chronic inflammatory rheumatic conditions with high levels of comorbidity requiring additional therapeutic attention. We aimed to compare the 3-year c...
Auteurs: Veerle Stouten, Sofia Pazmino, P Verschueren, Pavlos Mamouris, Rene Westhovens, Kurt de Vlam, Delphine Bertrand, Kristien van der Elst, Bert Vaes et Diederik De Cock
1 December 2020 | ARTICLE
The effect of electronic audits and feedback in primary care and factors that contribute to their effectiveness: a systematic review
PURPOSE: The aim of this systematic review was (i) to assess whether electronic audit and feedback (A&F) is effective in primary care and (ii) to evaluate important features concerning content and delivery of the feedback in primary care, includin...
Auteurs: Steve Van den Bulck, David Spitaels, Bert Vaes, Geert Goderis, Rosella Hermens et Patrik Vankrunkelsven
21 October 2020 | ARTICLE
Coding Systems for Clinical Decision Support: Theoretical and Real-World Comparative Analysis
BACKGROUND: Effective clinical decision support systems require accurate translation of practice recommendations into machine-readable artifacts; developing code sets that represent clinical concepts are an important step in this process. Many cli...
Auteurs: Nicolas Delvaux, Bert Vaes, Bert Aertgeerts, Stijn Van de Velde, Robert Vander Stichele, Peter Nyberg et Mieke Vermandere
8 March 2020 | ARTICLE
The incidence of lower respiratory tract infections and pneumococcal vaccination status in adults in flemish primary care
Pneumococcal vaccination coverage of adults at risk for pneumococcal disease is below recommended levels. There is no observational data on pneumococcal vaccination and the incidence of lower respiratory tract infections in a general adult populat...
Auteurs: Tine De Burghgraeve, Severine Henrard, Bart Verboven, Gijs Van Pottelbergh, Bert Vaes et Catharina Mathei
Auteurs: Lisa Hermans, Geert Molenberghs, Geert Verbeke, Michael G Kenward, Pavlos Mamouris et Bert Vaes
1 January 2020 | ARTICLE
The epidemiology of knee osteoarthritis in general practice: a registry-based study
OBJECTIVES: The present study investigated (1) trends in the prevalence and incidence of knee osteoarthritis over a 20-year period (1996-2015); (2) trends in multimorbidity and (3) trends in drug prescriptions. DESIGN: Registry-based study. SETTIN...
Auteurs: David Spitaels, Pavlos Mamouris, Bert Vaes, Miek Smeets, Frank Luyten, Rosella Hermens et Patrick Vankrunkelsven
Auteurs: Sofia Pazmino, Veerle Stouten, Patrick Verschueren, Pavlos Mamouris, Rene Westhovens, Kurt De Vlam, Delphine Bertrand, Kristien Van der Elst, Bert Vaes et Diederik De Cock
Auteurs: Thomas Struyf, Shauni Nuyts, Jos Tournoy, Bert Vaes et Ann Van den Bruel
Auteurs: Alvaro J Florez, Geert Molenberghs, Geert Verbeke, Michael G Kenward, Pavlos Mamouris et Bert Vaes
Auteurs: Sofia Pazmino, Veerle Stouten, Patrick Verschueren, Pavlos Mamouris, Rene Westhovens, Kurt de Vlam, Delphine Bertrand, Kristien Van der Elst, Bert Vaes et Diederik De Cock
1 June 2019 | ARTICLE
Burden of heart failure in Flemish general practices: a registry-based study in the Intego database
OBJECTIVES: To assess the prevalence and incidence of heart failure (HF) stages A to C/D and their evolution over a 16-year period. Additionally, trends in comorbidities and cardiovascular (CV) treatment in patients with HF were studied in the sam...
Auteurs: Miek Smeets, Bert Vaes, Pavlos Mamouris, Marjan Van den Akker, Gijs Van Pottelbergh, Geert Goderis, Stefan Janssens, Bert Aertgeerts et Severine Henrard
1 May 2019 | ARTICLE
Assessing testing rates for viral hepatitis B and C by general practitioners in Flanders, Belgium: a registry-based study
OBJECTIVES: Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) have a major impact on mortality worldwide. Although effective treatments are available for both HBV and HCV infection, < /50% of the patients are even diagnos...
Auteurs: Rob Bielen, Ozgur M Koc, Dana Busschots, Geert Robaeys, Bert Aertgeerts, Bert Vaes, Pavlos Mamouris, Catharina Mathei, Geert Goderis et Frederik Nevens
12 February 2019 | ARTICLE
Trends in multimorbidity and polypharmacy in the Flemish-Belgian population between 2000 and 2015
OBJECTIVES: The aim of this paper was to describe the time trends in the prevalence of multimorbidity and polypharmacy in Flanders (Belgium) between 2000 and 2015, while controlling for age and sex. METHODS: Data were available from Intego, a Flem...
Auteurs: Marjan van den Akker, Bert Vaes, Geert Goderis, Gijs Van Pottelbergh, Tine De Burghgraeve et Severine Henrard
1 January 2019 | ARTICLE
The health and economic impact of acute gastroenteritis in Belgium, 2010-2014
Acute gastroenteritis (AGE) remains a common condition in both low- and high-income countries. In Belgium, however, there is currently a lack of information on the societal health and economic impact of AGE. We conducted a retrospective study usin...
Auteurs: Theofilos Papadopoulos, Sofieke Klamer, Stephanie Jacquinet, Boudewijn Catry, Amber Litzroth, Laure Mortgat, Pavlos Mamouris, Javiera Rebolledo, Bert Vaes, Dieter Van Cauteren, Johan Van Der Heyden, Philippe Beutels et Brecht Devleesschauwer