Publicaties

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Auteurs: Katrien Danhieux, Marieke Hollevoet, Sien Lismont, Pieter Taveirne, Lotte Van Vaerenbergh, Bert Vaes et Steve van den Bulck
Auteurs: Arne Janssens, Bert Vaes, Gijs Van Pottelbergh, Pieter Libin et Thomas Neyens
21 May 2024 | ARTICLE
Using a general practice research database to assess the spatio-temporal COVID-19 risk.

BACKGROUND: In Flanders, general practitioners (GPs) were among the first ones to collect data regarding COVID-19 cases. Intego is a GPs' morbidity registry in primary care with data collected from the electronic medical records from a sample o...

Auteurs: Oana Petrof, Thomas Neyens, Bert Vaes, Arne Janssens et Christel Faes
13 May 2024 | ARTICLE
Association between non-registration of chronic kidney disease and mortality and cardiovascular outcome: a time-to-event analysis of retrospective primary care data.

OBJECTIVE: Patients with impaired kidney function and increased albuminuria are at risk of developing cardiovascular disease (CVD). Previous research has revealed that a substantial proportion of patients with chronic kidney disease (CKD) do no...

Auteurs: Ine Van den Wyngaert, Pavlos Mamouris, Endale Alemayehu Ali, Bert Vaes et Gijs Van Pottelbergh
1 May 2024 | ARTICLE
Epidemiology of functional dyspepsia and gastroparesis as diagnosed in Flemish-Belgian primary care: A registry-based study from the Intego database

BACKGROUND: Dyspepsia is a prevalent condition in the general population. Besides organic causes, the differential diagnosis of dyspepsia includes functional dyspepsia (FD) and gastroparesis (GP) which share similar pathophysiological mechanism...

Auteurs: I-Hsuan Huang, Jolien Schol, Guohao Lin, Yaozhu J Chen, Florencia Carbone, Bert Vaes et Jan Tack
1 March 2024 | ARTICLE
Assessing mental health from registry data: What is the best proxy?

OBJECTIVE: Medical registries frequently underestimate the prevalence of health problems compared with surveys. This study aimed to determine the registry variables that can serve as a proxy for variables studied in a mental health survey. MATE...

Auteurs: Simon Gabriel Beerten, Robby De Pauw, Gijs Van Pottelbergh, Lidia Casas et Bert Vaes
23 February 2024 | OTHER
Temporal trends in antibiotic prescribing and (non)serious infections in children presenting to general practice: a registry-based longitudinal cohort study of 162,507 individuals

BACKGROUND: It is crucial to understand the trends in paediatric antibiotic prescribing and serious and nonserious infections to improve antibiotic prescribing practices for children in ambulatory care. OBJECTIVES: Assessing trends in paediatri...

Auteurs: Ruben Burvenich, Sien De Boodt, Lien Lowie, Arne Janssens, simon Beerten, bert Vaes, jaan Toelen et jan Verbakel
27 September 2023 | ARTICLE
A longitudinal transition imputation model for categorical data applied to a large registry dataset

Imputation of longitudinal categorical covariates with several waves and many predictors is cumbersome in terms of implausible transitions, colinearity, and overfitting. We designed a simulation study with data obtained from a general practitio...

Auteurs: Pavlos Mamouris, Vahid Nassiri, Geert Verbeke, Arne Janssens, Bert Vaes et Geert Molenberghs
6 July 2023 | ARTICLE
Pneumococcal vaccination coverage and adherence to recommended dosing schedules in adults: a repeated cross-sectional study of the INTEGO morbidity registry

BACKGROUND: Since 2014, Belgium's Superior Health Council has recommended pneumococcal vaccination for adults aged 19-85 years at increased risk for pneumococcal diseases with a specific vaccine administration sequence and timing. Currentl...

Auteurs: Arne Janssens, Bert Vaes, Chloe Abels, Jonas Crevecoeur, Pavlos Mamouris, Barbara Merckx, Pieter Libin, Gijs Van Pottelbergh et Thomas Neyens
21 April 2023 | ARTICLE
The health and economic burden of musculoskeletal disorders in Belgium from 2013 to 2018

INTRODUCTION: Low back pain (LBP), neck pain (NKP), osteoarthritis (OST) and rheumatoid arthritis (RHE) are among the musculoskeletal (MSK) disorders causing the greatest disability in terms of Years Lived with Disability. The current study aim...

Auteurs: Vanessa Gorasso, Johan van der Heyden, Robby De Pauw, Ingrid Pelgrims, Eva M De Clercq, Karin De Ridder, Stefanie Vandevijvere, Stijn Vansteelandt, Bert Vaes, Delphine De Smedt et Brecht Devleesschauwer
7 April 2023 | ARTICLE
Trends in oral anticoagulant prescription in patients with nonvalvular atrial fibrillation in Flanders and the impact of switching patients from vitamin K antagonists to DOACS in terms of the burden caused by complications of the disease: a registry-based study

CONTEXT: Since the introduction of direct oral anticoagulants (DOACs) for the treatment of nonvalvular atrial fibrillation (Afib), oral anticoagulants (OACs) prescription has evolved. AIM: We aim first to explore the OACs prescription behaviour...

Auteurs: Elvire Nakhoul, Bert Vaes, Pavlos Mamouris et Jean-Marie Degryse
11 January 2023 | ARTICLE
Predictors for unplanned hospital admissions in community dwelling adults: A dynamic cohort study.

BACKGROUND: Polypharmacy and inappropriate medication use are associated with unplanned hospital admissions. Targeted interventions might reduce the hospitalization risk. Yet, it remains unclear which patient profiles derive the largest benefit...

Auteurs: Julie Hias, Laura Hellemans, Shauni Nuyts, Bert Vaes, Xavier Rygaert, Jos Tournoy et Lorenz Van der Linden
6 January 2023 | ARTICLE
Trends in the registration of anxiety in Belgian primary care from 2000 to 2021: a registry-based study

BACKGROUND: Anxiety is frequently encountered in general practice, but figures regarding prevalence and incidence in this healthcare setting remain scarce. AIM: To provide insight about the trends in prevalence and incidence of anxiety in Belgi...

Auteurs: Simon Beerten, Kristien Coteur, Pavlos Mamouris, Marc Van Nuland, Gijs Van Pottelbergh, Lidia Casas et Bert Vaes
1 January 2023 | ARTICLE
The Impact of the COVID-19 Pandemic on the Registration and Care Provision of Mental Health Problems in General Practice: Registry-Based Study

BACKGROUND: The impact of the COVID-19 pandemic on mental health in general practice remains uncertain. Several studies showed an increase in terms of mental health problems during the pandemic. In Belgium, especially during the first waves of ...

Auteurs: Jan Vandamme, Simon Gabriel Beerten, Jonas Crevecoeur, Steve Van den Bulck, Bert Aertgeerts, Nicolas Delvaux, Gijs Van Pottelbergh, Mieke Vermandere, Laura Tops, Thomas Neyens et Bert Vaes
22 December 2022 | ARTICLE
An exploration of under-registration of chronic kidney disease stages 3-5 in Belgian general practices using logistic regression

BACKGROUND: Early detection and treatment of chronic kidney disease (CKD) can prevent further deterioration and complications. Previous studies suggested that the diagnosis is often made when advanced renal failure occurs. The aims of this stud...

Auteurs: Ine Van den Wyngaert, Pavlos Mamouris, Bert Vaes et Gijs Van Pottelbergh
28 October 2022 | OTHER
Automated audit & feedback as a tool to implement antibiotic stewardship in primary care using the Intego database

Automated audit & feedback as a tool to implement antibiotic stewardship in primary care using the Intego database

Auteurs: Steve Van den Bulck, Bert Vaes et Jan Verbakel
23 September 2022 | ARTICLE
Evolution of benzodiazepine receptor agonist prescriptions in general practice: A registry-based study

BACKGROUND: Contrary to most European guidelines, benzodiazepine receptor agonists (BZRA) are often used continuously at a low dosage, being the most common form of long-term use. In Belgium, BZRA use is monitored by analyzing self-report data ...

Auteurs: Kristien Coteur, Pavlos Mamouris, Bert Vaes, Marc Van Nuland, Catharina Mathei et Birgitte Schoenmakers
Auteurs: Simon Beerten, Jan Vandamme, jonas Crèvecoeur, steve Van den Bulck, bert Aertgeerts, nicolas Delvaux, gijs Van Pottelbergh, mieke Vermandere, laura Tops, thomas Neyens et bert Vaes
12 August 2022 | ARTICLE
Burden of COVID-19 on primary care in Belgium: a prospective nationwide observational study from March to August 2020

BACKGROUND: The COVID-19 outbreak had an important impact on general practice, for example the lack of personal protective equipment (PPE) and the switch to telephone consultations. We installed a monitoring instrument and reported the burden t...

Auteurs: Bert Vaes, Benedicte Vos, Maxime Foidart, Robrecht De Schreye, Diego Schrans, Hilde Philips, Bert Aertgeerts et Kris Doggen
20 July 2022 | ARTICLE
Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020)

BACKGROUND: To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. METHODS: A retrospective study using data from 45 to 104 general practices (2000 to ...

Auteurs: Hanne A Boon, Thomas Struyf, Jonas Crevecoeur, Nicolas Delvaux, Gijs Van Pottelbergh, Bert Vaes, Ann Van den Bruel et Jan Y Verbakel
28 June 2022 | ARTICLE
Trends in the epidemiology of depression and comorbidities from 2000 to 2019 in Belgium

BACKGROUND: Depression is a common mental disorder in family practice with an impact on global health. The aim of this study is to provide insight in the trends of epidemiological measures as well as pharmacological treatments and comorbidities...

Auteurs: Roosje Walrave, Simon Gabriel Beerten, Pavlos Mamouris, Kristien Coteur, Marc Van Nuland, Gijs Van Pottelbergh, Lidia Casas et Bert Vaes
11 January 2022 | ARTICLE
Trends in prevalence and incidence of registered dementia and trends in multimorbidity among patients with dementia in general practice in Flanders, Belgium, 2000-2021: a registry-based, retrospective, longitudinal cohort study

OBJECTIVES: With the ageing of our population, it seems plausible that the prevalence of both dementia and multimorbidity will increase in the following decades. The aim of this study is to examine the trends in prevalence and incidence of regi...

Auteurs: Simon Gabriel Beerten, Antje Helsen, Jan De Lepeleire, Frans Boch Waldorff et Bert Vaes
1 January 2022 | ARTICLE
The impact of the Covid-19 pandemic on the incidence of diseases and the provision of primary care: A registry-based study.

INTRODUCTION: The Covid-19 pandemic had a tremendous impact on healthcare but uncertainty remains about the extent to which primary care provision was affected. Therefore, this paper aims to assess the impact on primary care provision and the e...

Auteurs: Steve Van den Bulck, Jonas Crèvecoeur, Bert Aertgeerts, Nicolas Delvaux, Thomas Neyens, Gijs Van Pottelbergh, Patrick Coursier et Bert Vaes
30 December 2021 | ARTICLE
Pneumococcal vaccination prevented severe LRTIs in adults: a causal inference framework applied in registry data

OBJECTIVES: We estimated the effect of pneumococcal vaccination (PV) on acute lower respiratory tract infections (LRTIs) in various age and risk groups using different methods within a causal inference methodological framework. STUDY DESIGN AND...

Auteurs: Pavlos Mamouris, Severine Henrard, Geert Molenberghs, Jan Verhaegen, Guohao Lin et Bert Vaes
17 September 2021 | ARTICLE
An automated data cleaning method for Electronic Health Records by incorporating clinical knowledge

BACKGROUND: The use of Electronic Health Records (EHR) data in clinical research is incredibly increasing, but the abundancy of data resources raises the challenge of data cleaning. It can save time if the data cleaning can be done automaticall...

Auteurs: Xi Shi, Charlotte Prins, Gijs Van Pottelbergh, Pavlos Mamouris, Bert Vaes et Bart De Moor
21 June 2021 | ARTICLE
Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study

AIMS: This study aims to assess the prevalence of atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), chronic kidney disease (CKD), and their combined presence in type 2 diabetes (T2D) patients in primary care for whom the 2019 ...

Auteurs: Geert Goderis, Bert Vaes, Pavlos Mamouris, Eline van Craeyveld et Chantal Mathieu
5 April 2021 | ARTICLE
The effect of automated audit and feedback on data completeness in the electronic health record of the general physician: protocol for a cluster randomized controlled trial

BACKGROUND: The electronic health record (EHR) of the general physician (GP) is an important tool that can be used to assess and improve the quality of healthcare. However, there are some problems when (re) using the data gathered in the EHR fo...

Auteurs: Steve van den Bulck, Tine De Burghgraeve, Willem Raat, Pavlos Mamouris, Patrick Coursier, Patrik Vankrunkelsven, Geert Goderis, Rosella Hermens, Gijs Van Pottelbergh et Bert Vaes
1 March 2021 | ARTICLE
Polypharmacy and excessive polypharmacy in community-dwelling middle aged and aged adults between 2011 and 2015

AIMS: We aimed to assess the prevalence, components and evolution of polypharmacy and to evaluate risk factors associated with polypharmacy. METHODS: A retrospective dynamic cohort study was performed, using a primary healthcare database compri...

Auteurs: Laura Hellemans, Shauni Nuyts, Julie Hias, Marjan van den Akker, Gijs Van Pottelbergh, Xavier Rygaert, Isabel Spriet, Bert Vaes, Jos Tournoy et Lorenz van der Linden
4 February 2021 | ARTICLE
Fast and optimal algorithm for case-control matching using registry data: application on the antibiotics use of colorectal cancer patients

BACKGROUND: In case-control studies most algorithms allow the controls to be sampled several times, which is not always optimal. If many controls are available and adjustment for several covariates is necessary, matching without replacement mig...

Auteurs: Pavlos Mamouris, Vahid Nassiri, Geert Molenberghs, Marjan van den Akker, Joep van der Meer et Bert Vaes
12 January 2021 | ARTICLE
Use of antibiotics and colorectal cancer risk: a primary care nested case-control study in Belgium

OBJECTIVES: To examine the association between the use of oral antibiotics and subsequent colorectal cancer risk. DESIGN: Matched case-control study. SETTING: General practice centres participating in the Integrated Computerised Network databas...

Auteurs: Johannes Van der Meer, Pavlos Mamouris, Vahid Nassiri, Bert Vaes et Marjan van den Akker